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Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

Dosage Regimens: Designs and Approaches

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

Dosage Regimen: Fixed Dose

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

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Related Experiment Video

Updated: Jun 23, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

[Repeat prescription management systems: strategy for optimising their use].

Eva Llobet Traveset¹, Rosa Madridejos Mora¹, Rosa Tomás Sanz¹

¹CAP Rambla, Unidad de Farmacia de Atención Primaria, Mútua de Terrassa, Terrassa, Barcelona, España.

Atencion Primaria

|May 12, 2009

Summary

A pharmacist-led educational intervention significantly improved patient punctuality in collecting repeat prescriptions. This simple approach enhanced medication adherence among individuals with chronic conditions.

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Improving IV Insulin Administration in a Community Hospital

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Published on: June 11, 2012

Area of Science:

Pharmacology and Patient Adherence
Primary Health Care Research
Health Education Strategies

Context:

Patient non-compliance with repeat prescription collection is a significant issue in primary healthcare.
Understanding patient-reported reasons for unpunctuality is crucial for developing effective interventions.
Repeat prescription management systems are vital for managing chronic diseases.

Purpose:

To improve patient compliance with repeat prescription systems.
To identify reasons for prescription collection delays.
To evaluate the effectiveness of an informative-educational intervention.

Summary:

A quasi-experimental study involving 200 patients with chronic diseases demonstrated that an informative-educational session with a pharmacist improved prescription collection punctuality by 17% in the intervention group.
The intervention group showed 60% punctuality compared to 43% in the control group, with women being more punctual.
No significant differences in punctuality were observed based on age, number of medications, or specific reasons for unpunctuality.

Impact:

Simple, pharmacist-led educational interventions can effectively enhance patient adherence to repeat prescription systems.
Improved medication adherence can lead to better health outcomes for patients with chronic conditions.
This study highlights a scalable and cost-effective method for improving primary healthcare service delivery.