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Published on: September 19, 2025
History of mechanical ventilation may affect respiratory mechanics evolution in acute respiratory distress syndrome
Antonia Koutsoukou1, Helen Perraki, Stylianos E Orfanos
1Critical Care Department and Pulmonary Services, Evangelismos General Hospital, University of Athens Medical School, GR-10675 Athens, Greece. koutsoukou@yahoo.gr
Purpose:
The aim of this study was to investigate the effect of mechanical ventilation (MV) before acute respiratory distress syndrome (ARDS) on subsequent evolution of respiratory mechanics and blood gases in protectively ventilated patients with ARDS.
Methods:
Nineteen patients with ARDS were stratified into 2 groups according to ARDS onset relative to the onset of MV: In group A (n = 11), MV was applied at the onset of ARDS; in group B (n = 8), MV had been initiated before ARDS. Respiratory mechanics and arterial blood gas were assessed in early (
Results:
In group A, Pao(2)/fractional inspired oxygen concentration increased (121 +/- 43 vs 161 +/- 60 mm Hg) and minimal resistance of respiratory system decreased (8.3 +/- 1.8 vs 6.0 +/- 2.1 cm H(2)O L(-1) s(-1)) from early to late ARDS. In group B, static elastance of respiratory system increased in the late stage (30.4 +/- 7.8 vs 36.4 +/- 9.9 cm H(2)O/L). In both groups, positive end-expiratory pressure application resulted in Pao(2)/fractional inspired oxygen concentration improvement and minimal resistance of respiratory system decreases in both stages.
Conclusion:
In protectively ventilated patients with ARDS, late alteration of respiratory mechanics occurs more commonly in patients who have been ventilated before ARDS onset, suggesting that the history of MV affects the subsequent progress of ARDS even when using protective ventilation.
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Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation: