Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Cholinergic Antagonists: Therapeutic Uses01:26

Cholinergic Antagonists: Therapeutic Uses

Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The introduction of gluten into the infant diet. Expert group recommendations].

Anales de pediatria (Barcelona, Spain : 2003)·2015
Same author

[Inherited metabolic disorders in pediatric emergency services].

Anales de pediatria (Barcelona, Spain : 2003)·2014
Same author

[Nutrition recommendations for children who practice sports].

Anales de pediatria (Barcelona, Spain : 2003)·2013
Same author

[Nutritional problems perceived by pediatricians in Spanish children younger than 3 years].

Nutricion hospitalaria·2013
Same author

[Validation of a nutritional screening tool for hospitalized pediatric patients].

Nutricion hospitalaria·2013
Same author

[Recommended intake of calcium and vitamin D: positioning of the Nutrition Committee of the AEP].

Anales de pediatria (Barcelona, Spain : 2003)·2012

Related Experiment Video

Updated: Jun 23, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

[Hypercholesterolemia: a therapeutic approach].

A Moráis López1, R A Lama More, J Dalmau Serra

  • 1Unidad de Nutrición Infantil y Enfermedades Metabólicas, Hospital Universitario Infantil La Paz, Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|May 12, 2009
PubMed
Summary

High cholesterol in children, or hypercholesterolemia, is a cardiovascular risk. Screening and lifestyle changes are key, with medication considered for older children with persistent high LDL cholesterol levels.

More Related Videos

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Related Experiment Videos

Last Updated: Jun 23, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Area of Science:

  • Pediatric Cardiology
  • Metabolic Disorders
  • Public Health

Context:

  • High blood cholesterol is a significant cardiovascular risk factor.
  • Hypercholesterolemia is defined as total cholesterol and LDL cholesterol above the 95th percentile for age and gender.
  • Selective screening is advised for children over 2 years who are overweight, have a family history of early cardiovascular disease, or parental hypercholesterolemia.

Purpose:

  • To outline screening recommendations for pediatric hypercholesterolemia.
  • To detail initial therapeutic approaches including lifestyle modifications.
  • To establish criteria for initiating drug treatment in children.

Summary:

  • Initial management involves diet, physical activity, and lifestyle changes.
  • Drug treatment is considered for children aged 10+ with persistent high LDL cholesterol or moderate levels with risk factors.
  • Earlier drug intervention (age 8) may be considered for extremely high LDL cholesterol levels.
  • Statins are recommended as first-choice drugs, with bile acid-binding resins showing a modest response.

Impact:

  • Provides guidance for identifying and managing high cholesterol in children.
  • Emphasizes a stepwise approach to treatment, prioritizing lifestyle interventions.
  • Supports the early detection and management of pediatric cardiovascular risk factors.