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Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps.

Bernt Tore Bråtane¹, Birgul Bastan, Marc Fisher

¹Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Bernt.Bratane@umassmed.edu

|May 12, 2009

Summary

This summary is machine-generated.

Diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps assess ischemic stroke lesions. ADC map analysis more accurately predicts final infarcts and reveals lesion reversibility compared to DWI.

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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

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Area of Science:

Neuroscience
Radiology
Medical Imaging

Background:

Diffusion weighted imaging (DWI) is crucial for identifying ischemic lesions in focal cerebral ischemia.
Accurate spatiotemporal evolution patterns of lesions using different analysis methods require further understanding.

Purpose of the Study:

To compare the accuracy of different analysis methods for determining ischemic lesion volumes.
To evaluate the correlation of imaging-derived lesion volumes with actual infarct volumes.
To assess the reliability and information provided by apparent diffusion coefficient (ADC) maps versus DWI.

Main Methods:

Serial DWI and ADC maps were acquired in rat stroke models (MCAO) with varying occlusion durations.
Lesion volumes were analyzed using ADC thresholding, visual ADC hypointensity, and visual DWI hyperintensity.
Imaging-derived lesion volumes were correlated with 2,3,5-triphenyltetrazoliumchloride (TTC)-derived infarct volumes.

Main Results:

ADC and DWI lesion volumes correlated with TTC infarct volumes, with ADC showing a stronger correlation.
Lesion volumes on ADC maps decreased post-reperfusion, while DWI volumes remained unchanged.
Visual ADC map analysis demonstrated better interrater agreement and stronger correlation with threshold-derived volumes than visual DWI analysis.

Conclusions:

Apparent diffusion coefficient (ADC) map analysis is more accurate for predicting final infarcts and assessing lesion reversibility.
ADC analysis offers rater-independent insights into ischemic lesion evolution.
ADC maps provide unique information on ischemic lesion reversibility not available with DWI alone.