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Updated: Jun 23, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Photon activation therapy and brachytherapy.

Brenda H Laster¹, Dabney W Dixon, Sara Novick

¹Department of Nuclear Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel. blaster@bgumail.bgu.ac.il

|May 12, 2009

Summary

This summary is machine-generated.

Photon activation therapy (PAT) using platinum (Pt) and palladium-103 seeds slowed tumor growth in mice by inducing Auger electron emission. This targeted approach enhanced DNA damage for potential cancer treatment applications.

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Area of Science:

Oncology
Medical Physics
Radiochemistry

Background:

Photon activation therapy (PAT) aims to enhance localized radiation dose in tumors.
High Z atoms complexed with DNA can amplify energy deposition via the photoelectric effect.
Auger electron emission, triggered by photoelectric effect, can cause significant local DNA damage.

Purpose of the Study:

To evaluate the efficacy of PAT in vivo.
To investigate the use of X-rays from palladium-103 seeds to excite platinum (Pt) atoms bound to DNA.
To assess the impact on cancerous cell DNA in murine models.

Main Methods:

Utilized Pt (II) tetrakis(N-methyl-4-pyridyl) porphyrin chloride to bind Pt atoms to DNA in KHJJ murine mammary carcinoma.
Implanted a 2.3-mCi palladium-103 seed directly into the tumor.
Monitored tumor growth rates in treated and control groups.

Main Results:

Tumor periphery received subtherapeutic radiation doses.
Mice treated with PAT exhibited a slower tumor growth rate compared to those receiving only brachytherapy.
Evidence suggests localized damage due to Auger electron emission from Pt atoms.

Conclusions:

Tumor growth delay in PAT-treated mice is likely due to Auger electron emission from Pt atoms, causing significant local DNA damage.
The study supports the hypothesis that PAT can enhance tumor cell killing.
Further research is needed to rule out other contributing mechanisms.