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Updated: Jun 23, 2026

Gas Chromatography-Mass Spectrometry-Based Targeted Metabolomics of Hard Coral Samples
Published on: October 13, 2023
New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli
Shi-Yie Cheng1, Ya-Chiang Huang, Zhi-Hong Wen
1Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Abstract:
Chemical investigation of the Formosan soft coral Nephthea chabroli resulted in the isolation of four new 19-oxygenated steroids, nebrosteroids I-L (1-4), together with a new 4alpha-methylated steroid, nebrosteroid M (5). The molecular structures of these isolated metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Compounds 1-5 were evaluated for anti-inflammatory activity using RAW 264.7 macrophages.
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