Related Experiment Video
Updated: Jun 23, 2026

Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
Published on: October 19, 2016
Visualization of spiral ganglion neurites within the scala tympani with a cochlear implant in situ
Jennifer A Chikar1, Shelley A Batts, Bryan E Pfingst
1Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1150 W. Medical Center Drive, Room 4605 Med Sci II, Ann Arbor, MI 48109-5616, USA.
Abstract:
Current cochlear histology methods do not allow in situ processing of cochlear implants. The metal components of the implant preclude standard embedding and mid-modiolar sectioning, and whole mounts do not have the spatial resolution needed to view the implant within the scala tympani. One focus of recent auditory research is the regeneration of structures within the cochlea, particularly the ganglion cells and their processes, and there are multiple potential benefits to cochlear implant users from this work. To facilitate experimental investigations of auditory nerve regeneration performed in conjunction with cochlear implantation, it is critical to visualize the cochlear tissue and the implant together to determine if the nerve has made contact with the implant. This paper presents a novel histological technique that enables simultaneous visualization of the in situ cochlear implant and neurofilament-labeled nerve processes within the scala tympani, and the spatial relationship between them.
Related Concept Videos
Auditory Pathway
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
The Cochlea
Anatomy of the Ear
Hair Cells

