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Updated: Jun 23, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
An exopolysaccharide produced by Geobacillus thermodenitrificans strain B3-72: antiviral activity on immunocompetent
Adriana Arena1, Concetta Gugliandolo, Giovanna Stassi
1Department of Surgical Science, Unit of Microbiology, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.
Abstract:
The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells. In fact, high levels of IFN-alpha, IL-12, IFN-gamma, TNF-alpha, IL-18 were detected in supernatants of EPS-2 treated PBMC. Moreover, this effect was dose-dependent. Taken together, our results confirm that the immunological disorders determined by HSV-2 could be partially restored by treatment with EPS-2.
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