Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Incidence of nosocomial pneumonia and clinical outcomes of patients requiring non-invasive ventilation: A systematic review and meta-analysis.

The Southern African journal of critical care : the official journal of the Critical Care Society·2026

Same author

Polarimetric backscattering setup for quantitative scattering parameters retrieval.

Optics express·2026

Same author

Intraoperative management of recurrent laryngeal nerve invasion in thyroid carcinoma: Oncologic and functional outcomes with a surgical decision algorithm.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026

Same author

Machine learning based prediction of single-frequency viscoelastic brain white matter - A data science framework.

Computers in biology and medicine·2025

Same author

Glandular cardiac myxomas: Pathological features and histogenesis.

Journal of postgraduate medicine·2025

Same author

Neoadjuvant Chemotherapy Followed by Surgery-A Promising Strategy to Reduce Morbidity in Locally Advanced Tongue Cancer.

Head & neck·2025

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

Mapping the complement C1q binding site in Haemonchus contortus calreticulin.

S Naresha¹, A Suryawanshi, M Agarwal

¹Division of Biochemistry, Indian Veterinary Research Institute, Izatnagar, UP, India.

Molecular and Biochemical Parasitology

|May 12, 2009

Summary

Haemonchus contortus parasite calreticulin (CalR) inhibits host immunity by binding complement C1q. Researchers identified two new C1q binding sites on H. contortus CalR, crucial for understanding host-parasite interactions.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

Related Experiment Videos

Last Updated: Jun 23, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

Area of Science:

Parasitology
Immunology
Biochemistry

Background:

Haemonchus contortus is a significant gastrointestinal parasite affecting domestic animals.
The parasite releases calreticulin (CalR), a calcium-binding protein that influences the host immune system.
CalR inhibits the classical complement pathway by interacting with complement C1q protein.

Purpose of the Study:

To map the specific regions within the N-domain of H. contortus calreticulin responsible for binding to complement C1q.
To identify novel C1q binding sites on H. contortus calreticulin.

Main Methods:

Generation of small recombinant fragments of the N-domain of H. contortus calreticulin.
Utilizing synthetic peptides to probe C1q binding interactions.
Mapping of C1q binding sites on the N-domain of H. contortus calreticulin.

Main Results:

Two novel C1q binding sites were identified in the N-domain of H. contortus calreticulin.
The newly discovered binding sites have sequences GKYYDDAKRD and AKFPKKFT.
These findings expand upon previously identified C1q binding motifs in human calreticulin.

Conclusions:

The study reveals multiple C1q binding motifs in H. contortus calreticulin.
Understanding these interactions is vital for developing strategies to bolster host immune responses against H. contortus.
The identified motifs provide insights into host-parasite immune modulation mechanisms.