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Effectiveness of two pertussis vaccines in preterm Danish children

Anders Hviid1

  • 1Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen S, Denmark. aii@ssi.dk

Vaccine
|May 12, 2009
PubMed

Insights

Preterm infants show reduced immune response to pertussis vaccines. However, vaccination effectiveness for pertussis (whooping cough) was found to be similar in both preterm and full-term children after completing the primary series.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • Pertussis (whooping cough) vaccines exhibit reduced immunogenicity in preterm infants.
  • The relationship between immunogenicity and clinical protection against pertussis is not fully understood.
  • The impact of reduced immunogenicity on post-licensure vaccine effectiveness in preterm children remains undetermined.

Purpose of the Study:

  • To evaluate the effectiveness of pertussis vaccination in preterm versus full-term children.
  • To compare the effectiveness of both whole-cell and acellular pertussis vaccines in these populations.

Main Methods:

  • A nationwide cohort study was conducted in Denmark.
  • The study included 879,424 children, with 1553 cases of pertussis hospitalization.
  • Vaccine effectiveness was analyzed for both preterm and full-term children.

Main Results:

  • The effectiveness of a completed primary series of pertussis vaccination was similar between preterm and full-term children.
  • This similarity in effectiveness was observed for both whole-cell and acellular pertussis vaccines.

Conclusions:

  • Completed primary pertussis vaccination series provide similar effectiveness in preterm and full-term children.
  • Despite potential differences in immunogenicity, clinical protection appears comparable, supporting current vaccination strategies for preterm infants.

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