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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...

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Related Experiment Video

Updated: Jun 23, 2026

Cholesterol Efflux Assay
07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

New functions of cholesterol binding proteins.

Jun-Ping Liu1

  • 1Department of Immunology, Monash University Central Clinical School, Prahran, Victoria, Australia. jun-ping.liu@med.monash.edu.au

Molecular and Cellular Endocrinology
|May 12, 2009
PubMed
Summary

Cholesterol and glucose interact with transcription factors, influencing gene expression and cellular metabolism. This review explores new roles of cholesterol-binding proteins in regulating lipid homeostasis and cellular functions.

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Last Updated: Jun 23, 2026

Cholesterol Efflux Assay
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Published on: March 6, 2012

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10:12

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Area of Science:

  • Molecular Biology
  • Cellular Metabolism
  • Lipid Biochemistry

Background:

  • Cholesterol is vital for eukaryotic cell membranes and signal transduction.
  • Cholesterol and glucose share regulatory pathways involving transcription factors.
  • Sterol-binding proteins control lipid homeostasis and antigen presentation.

Purpose of the Study:

  • To review novel functions of cholesterol-binding proteins.
  • To explore molecular mechanisms of sterol sensors responding to glucose and other ligands.
  • To propose new models for cholesterol homeostasis, function, and trafficking.

Main Methods:

  • Literature review of recent studies on cholesterol-binding proteins.
  • Analysis of molecular mechanisms involving sterol sensors.
  • Examination of studies on Insig, SCAP, LXR, HMG-CoAR, NPC1, and NPC2.

Main Results:

  • Cholesterol-binding proteins have newly identified roles in cholesterol homeostasis, function, and trafficking.
  • Sterol sensors integrate signals from glucose and other ligands to regulate metabolism.
  • New models highlight the complex interplay between sterols, glucose, and gene expression.

Conclusions:

  • Cholesterol-binding proteins are key regulators of cellular lipid metabolism and function.
  • Understanding these proteins offers insights into metabolic diseases.
  • Further research into sterol-ligand interactions can reveal new therapeutic targets.