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Updated: Jun 23, 2026

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development.

M B Levanti¹, I Esteban, E Ciriaco

¹Dipartimento di Morfologia, Biochimica, Fisiologia e Produzioni Animali, Università di Messina, Messina, Italy.

Neuroscience Letters

|May 12, 2009

Summary

Brain-derived neurotrophic factor receptor TrkB is essential for enteric nervous system (ENS) glial cell development and maintenance. TrkB deficiency in mice leads to reduced glial markers and disarranged ENS structure.

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Last Updated: Jun 23, 2026

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Published on: August 15, 2018

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The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

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Published on: April 14, 2013

Area of Science:

Neuroscience
Developmental Biology
Gastroenterology

Background:

Enteric nervous system (ENS) development relies on neurotrophic signaling.
Neurotrophins (NTs) and their Trk receptors regulate peripheral nervous system development.
TrkB is the high-affinity receptor for brain-derived neurotrophic factor (BDNF) and NT-4.

Purpose of the Study:

Investigate TrkB expression and localization in the murine ENS.
Determine the role of TrkB in ENS development and glial cell maintenance.

Main Methods:

Western blot analysis
Immunohistochemistry
Analysis of TrkB-deficient mice models

Main Results:

Enteric glial cells express full-length TrkB throughout ENS development.
TrkB-deficient mice exhibit reduced expression of glial cell markers.
TrkB deficiency causes disarrangement of glial cells and the ENS neuropil.

Conclusions:

TrkB signaling is crucial for the normal development and maintenance of ENS glial cells.
TrkB plays an essential role in maintaining the structural integrity of the ENS.