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Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Updated: Jun 23, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Reduced Morg1 expression in ischemic human brain.

Daniela Haase¹, Silke Keiner, Christian Mawrin

¹Department of Neuropathology, Friedrich-Schiller-University Jena, Germany.

Neuroscience Letters

|May 12, 2009

Summary

This summary is machine-generated.

Mitogen-activated protein kinase organizer 1 (Morg1) is found in the human brain. Its expression decreases in ischemic brain tissue, potentially aiding hypoxic adaptation and recovery.

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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

Area of Science:

Neuroscience
Molecular Biology
Cell Biology

Background:

Mitogen-activated protein kinase organizer 1 (Morg1) is a scaffold protein regulating ERK signaling.
Morg1 influences hypoxia-inducible factor-1alpha (HIF-1alpha) expression via prolyl-hydroxylase 3 (PHD3).

Purpose of the Study:

To investigate Morg1 expression in the human brain, particularly in the context of ischemic damage.
To understand the role of Morg1 in neuronal and glial cells during brain injury.

Main Methods:

Immunohistochemistry was used to detect Morg1 protein in human brain tissue.
RT real-time PCR and Western blotting were employed to quantify Morg1 expression levels.
Analysis focused on brain tissue with and without ischemic damage, including surrounding reactive astrocytes.

Main Results:

Morg1 is expressed in human brain neurons, glial cells, and blood vessel walls.
Morg1 expression is significantly reduced in brain tissue affected by ischemic damage.
Reactive astrocytes surrounding ischemic areas exhibit strong Morg1 expression.

Conclusions:

Reduced Morg1 expression in ischemic brain may promote adaptive responses, including HIF-1alpha-mediated tissue sparing and functional recovery.
Upregulation of Morg1 in astrocytes near the ischemic penumbra might counteract beneficial hypoxic adaptation mechanisms.