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[Tuberculosis and cystic fibrosis].

F Friedrichs1, G Kusenbach, H Skopnik

  • 1Kinderklinik der RWTH Aachen.

Klinische Padiatrie
|September 1, 1991
PubMed
Summary

This study found no increased risk of tuberculosis in Cystic Fibrosis patients, challenging the idea of enhanced host resistance in Cystic Fibrosis carriers against mycobacterial infections.

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Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Genetics

Context:

  • Cystic Fibrosis (CF) patients often have risk factors for mycobacterial infections, including underweight, diabetes, and chronic lung disease.
  • Glucocorticoid therapy is sometimes required for CF patients.
  • CF heterozygotes are hypothesized to have a protective advantage against Mycobacterium tuberculosis.

Purpose:

  • To investigate the incidence of tuberculin conversion and active Mycobacterium tuberculosis infection in a large cohort of Cystic Fibrosis patients in Germany.
  • To evaluate the hypothesis of increased host resistance against tuberculosis in CF patients and carriers.

Summary:

  • A survey of 1926 Cystic Fibrosis patients in the Federal Republic of Germany (FRG) was conducted to assess tuberculosis risk.
  • The study found no evidence to support the hypothesis of increased host resistance in CF patients or a higher risk of tuberculosis.
  • Results indicate that tuberculosis is not more common in CF patients than in the general population.

Impact:

  • Findings suggest current prophylactic, diagnostic, and therapeutic strategies for tuberculosis in CF patients may need re-evaluation based on updated epidemiologic data.
  • Challenges the long-held belief of selective advantage in CF heterozygotes regarding tuberculosis resistance.
  • Provides crucial data for public health policies concerning infectious disease management in Cystic Fibrosis care.

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