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Ferrous sulfate versus iron polymaltose complex for treatment of iron deficiency anemia in children

Ankur Vikas Bopche1, Rashmi Dwivedi, Rakesh Mishra

  • 1Department of Pediatrics, Kamla Nehru Hospital, Gandhi Medical College and Associated Hamidia Hospital, Bhopal, MP, India.

Indian Pediatrics
|May 12, 2009
PubMed

Insights

Ferrous sulfate showed better clinical response and fewer side effects than iron polymaltose complex in treating pediatric iron deficiency anemia. This finding aids in selecting optimal iron therapy for children.

Area of Science:

  • Pediatric Hematology
  • Clinical Nutrition
  • Pharmacology

Background:

  • Iron deficiency anemia (IDA) is a prevalent nutritional disorder in children.
  • Effective iron supplementation is crucial for managing pediatric IDA.
  • Comparing different oral iron formulations is important for optimizing treatment outcomes.

Purpose of the Study:

  • To compare the clinical response and side effects of Ferrous sulfate (FS) and Iron polymaltose complex (IPC) in children with IDA.
  • To evaluate the efficacy and tolerability of two common oral iron therapies.

Main Methods:

  • A randomized controlled trial involving 118 children diagnosed with IDA.
  • Participants were assigned to receive either oral IPC or oral FS (6 mg/kg/day elemental iron, divided doses).
  • Clinical response (hemoglobin levels) and residual complaints were assessed in 106 followed-up children.

Main Results:

  • Children treated with Ferrous sulfate exhibited higher hemoglobin levels compared to those receiving Iron polymaltose complex.
  • The Ferrous sulfate group reported fewer residual complaints.
  • Adverse effects were less significant in the Ferrous sulfate group.

Conclusions:

  • Ferrous sulfate demonstrates a superior clinical response in treating pediatric iron deficiency anemia.
  • Ferrous sulfate is associated with fewer adverse effects compared to Iron polymaltose complex in this pediatric population.
  • These findings suggest Ferrous sulfate as a potentially more effective oral iron therapy for children with IDA.

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