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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Cytomegalovirus infection in six neonates

S S Yadav1, G Narula, S Narayan

  • 1Department of Pediatrics, INHS Asvini, Colaba, Mumbai, India.

Indian Pediatrics
|May 12, 2009
PubMed

Insights

Neonatal cytomegalovirus (CMV) infection requires prompt diagnosis. Ganciclovir treatment for persistent viremia can lead to clinical resolution and limit severe complications in newborns.

Area of Science:

  • Pediatrics
  • Virology
  • Infectious Diseases

Background:

  • Neonatal cytomegalovirus (CMV) infection is a prevalent condition with diverse clinical presentations and significant long-term consequences.
  • Early identification and management are crucial for mitigating severe sequelae.

Purpose of the Study:

  • To evaluate the clinical course and treatment outcomes of neonates diagnosed with cytomegalovirus (CMV) infection.
  • To assess the efficacy of Ganciclovir in managing persistent CMV viremia.

Main Methods:

  • Six neonates with suspected CMV infection were confirmed using qualitative PCR.
  • Patients with persistent viremia received intravenous Ganciclovir for 4-6 weeks, followed by oral therapy if necessary.
  • Clinical outcomes and complications were closely monitored.

Main Results:

  • All affected neonates presented with prolonged jaundice, hepatosplenomegaly, and hematological abnormalities.
  • Common complications included developmental delay (66%), sensorineural hearing loss (33%), chorioretinitis, and obstructive jaundice (18% each).
  • Two neonates completed Ganciclovir therapy, achieving clinical resolution without adverse events.

Conclusions:

  • Accurate diagnosis of neonatal CMV infection is essential for timely intervention.
  • Ganciclovir treatment demonstrates potential in reversing end-organ damage and limiting sequelae in affected neonates.

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