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Urinary tract infections: bacteriology and antibiotic resistance patterns

Rasoul Yousefi Mashouf1, Hooshang Babalhavaeji, Javad Yousef

  • 1Department of Medical Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. yousefimash@yahoo.com

Indian Pediatrics
|May 12, 2009
PubMed

Insights

Community-acquired urinary tract infections (UTIs) in Iranian children are frequently caused by E. coli. Many bacterial isolates exhibit significant antibiotic resistance, particularly Klebsiella species.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Community-acquired urinary tract infections (UTIs) are common in children.
  • Antibiotic resistance in pediatric UTIs is a growing global concern.
  • Understanding local resistance patterns is crucial for effective treatment.

Purpose of the Study:

  • To identify bacterial pathogens responsible for community-acquired UTIs in children under 18 in western Iran.
  • To determine the antibiotic resistance profiles of these bacterial isolates.

Main Methods:

  • A retrospective analysis of 912 pediatric patients with suspected UTIs.
  • Bacterial identification and antibiotic susceptibility testing using the gel-diffusion method against 14 antibiotics.
  • Data stratified by age groups: infants, toddlers, preteens, and teens.

Main Results:

  • 34.2% of patients had positive bacterial cultures.
  • The most prevalent uropathogens were E. coli (57.4%), K. pneumoniae (9.7%), S. aureus (5.8%), and A. baumannii (2.2%).
  • High resistance rates were observed for ampicillin, cotrimoxazole, nalidixic acid, tobramycin, and nitrofurantoin. Klebsiella isolates demonstrated greater resistance than E. coli.

Conclusions:

  • E. coli is the primary cause of pediatric community-acquired UTIs in this region.
  • Significant antibiotic resistance exists among common uropathogens, necessitating careful antibiotic selection.
  • Age-specific resistance patterns warrant further investigation.

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