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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Jun 23, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Ophthalmoplegic migraine.

Semai Bek¹, Gencer Genc, Seref Demirkaya

¹Gulhane Medical Faculty, Department of Neurology, Etlik, Ankara, Turkey. semaibek@yahoo.com

The Neurologist

|May 12, 2009

Summary

This summary is machine-generated.

Ophthalmoplegic migraine, a condition involving headache and ocular nerve palsy, may stem from demyelination. This case study shows successful treatment with methylprednisolone, resolving symptoms and MRI findings.

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Published on: June 2, 2014

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Published on: September 13, 2024

Area of Science:

Neurology
Ophthalmology

Background:

Ophthalmoplegic migraine (OM) is characterized by recurrent headaches with migrainous features and cranial nerve palsies, typically affecting the third nerve.
The International Headache Society defines OM in the absence of intracranial lesions, with recent reclassification suggesting a demyelinating etiology over microvascular causes.

Observation:

A 21-year-old male presented with recurrent right frontal headaches, ptosis, and right eye adduction paralysis.
Clinical symptoms, including eyelid drooping and double vision, persisted for approximately 3 months.
Brain MRI revealed thickening and enhancement of the right oculomotor nerve.

Findings:

Treatment with intravenous methylprednisolone resulted in clinical improvement within two weeks.
Resolution of oculomotor nerve enhancement on MRI was observed three months post-treatment.
This case provides pre- and post-treatment documentation of oculomotor nerve thickening in ophthalmoplegic migraine.

Implications:

The findings support the reclassification of ophthalmoplegic migraine as a demyelinating condition.
Methylprednisolone may be an effective treatment for ophthalmoplegic migraine with oculomotor nerve involvement.
This case highlights the importance of neuroimaging and prompt treatment in managing ophthalmoplegic migraine.