In vitro pharmacodynamic activities of root canal sealers on Enterococcus faecalis
Related Experiment Video
Updated: Jun 23, 2026
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Burak Sagsen1, Ozgur Er, Duygu Esel
1Department of Operative Dentistry and Endodontics, Faculty of Dentistry, University of Erciyes, Kayseri, Turkey. buraksagsen@erciyes.edu.tr
Aim:
The aim of this study was to evaluate the antimicrobial efficiency of different root canal sealers on Enterococcus faecalis (E. Faecalis) at different time intervals.
Methods And Materials:
All sealers used were mixed according to the manufacturers' instructions then 75 mg of each sealer was added to different sterile tubes and evaluated at 20 minutes, 24 hours, 7 days, and 30 days. A time-kill assay (TKA) was used to determine the antimicrobial efficiency of the sealers.
Results:
AH Plus and MCS were found to be bactericidal at 20 minutes and 24 hours, but only MCS was bactericidal at the seventh and thirtieth days. Epiphany and Sealapex were found to be bacteriostatic at the seventh and thirtieth days but indifferent at 20 minutes and 24-hours. MCS and AH Plus were both found to be bactericidal in freshly mixed samples, but only MCS was bactericidal at longer time periods. Epiphany Sealer and Sealapex were found to be bacteriostatic at longer time periods but indifferent at 20 minutes and 24 hours.
Conclusion:
The antibacterial effect of MCS was greater than the other sealers evaluated.
Clinical Significance:
Sealers containing eugenol and epoxy resin might be preferable due to their antibacterial effect.
