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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

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Type I Diabetes I: Introduction01:12

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Modeling in Therapy01:26

Modeling in Therapy

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Participant Modeling
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

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Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Autoimmunity in autism.

Amanda M Enstrom1, Judy A Van de Water, Paul Ashwood

  • 1University of California at Davis, Department of Medical Microbiology and Immunology/UC Davis MIND Institute, 2805 50th Street, Sacramento, CA 95817, USA.

Current Opinion in Investigational Drugs (London, England : 2000)
|May 12, 2009
PubMed
Summary
This summary is machine-generated.

Investigating the immune system in autism spectrum disorder (ASD) is crucial. Autoimmune phenomena and maternal antibodies targeting the fetal brain suggest immune dysfunction may be a key factor in ASD development and a potential therapeutic target.

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Last Updated: Jun 23, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Area of Science:

  • Neuroimmunology
  • Developmental Neuroscience
  • Autism Spectrum Disorder Research

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with unknown causes.
  • Emerging evidence suggests autoimmune phenomena and immune system dysfunction in individuals with ASD.
  • Maternal antibodies targeting the fetal brain have been identified in some mothers of children with ASD.

Purpose of the Study:

  • To explore the role of immune system dysfunction in the development of autism spectrum disorder.
  • To investigate the potential of immune-related factors as novel therapeutic targets for ASD.
  • To understand the impact of maternal antibodies on fetal brain development in the context of ASD.

Main Methods:

  • Review of current evidence on autoimmune phenomena in ASD.
  • Analysis of studies detecting maternal antibodies against the fetal brain in ASD cohorts.
  • Examination of animal model data on the effects of these antibodies on behavior.

Main Results:

  • Increased evidence points to altered immune responses in individuals with ASD.
  • Maternal antibodies targeting the fetal brain are detected in some ASD cases.
  • These antibodies have demonstrated the capacity to alter behavioral outcomes in animal models.

Conclusions:

  • Immune system dysfunction may play a significant role in the etiology of ASD.
  • Identifying and targeting immune system alterations presents a promising avenue for novel ASD therapies.
  • Further understanding of immune involvement in early brain development is critical for therapeutic advancements in ASD.