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Severe neonatal renal failure after maternal use of angiotensin II type I receptor antagonists

M T Sinelli1, D Cattarelli, S Cortinovis

  • 1Division of Neonatology and Neonatal Intensive Care Unit, Spedali Civili, Pzzale Spedali Civili, 1-25100 Brescia.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|May 13, 2009
PubMed

Sartans are selective type 1 angiotensin II receptor antagonists that are used for treatment of arterial hypertension. We report a case of severe renal failure required dialysis after the use of olmesartan in the last month of pregnancy. Exposure to sartans during the last period of gestation seems to be associated with high risk of congenital malformations. It is important to stress that the use of these drugs during pregnancy must be avoided, especially in the third trimester.

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