[Lethal intravenous infusion of a wound antiseptic containing polyhexanide]

Area of Science:

• Toxicology
• Pharmacology
• Wound Care

Background:

• Polyhexamethylene biguanide (PHMB) is widely used as a highly histocompatible wound antiseptic.
• Previous reports of PHMB intoxication are rare, with only one case documented.
• The safety profile of PHMB in clinical settings is generally considered favorable.

Observation:

• A case of lethal intoxication following intravenous administration of PHMB is presented.
• This represents the first fatal incident where a direct temporal link between PHMB application and organ damage is established.
• The patient exhibited severe clinical manifestations consistent with systemic toxicity.

Findings:

• Laboratory and histological investigations confirmed the severe toxicity of PHMB upon intravenous exposure.
• Key findings included significant hepatic (liver) and pancreatic damage.
• Evidence suggests PHMB can induce acute organ injury at toxic doses.

Implications:

• This case highlights a critical, previously underestimated risk associated with intravenous PHMB administration.
• It underscores the importance of careful patient monitoring and dose control when using PHMB, especially via non-topical routes.
• Further research into the toxicological mechanisms and safe dosage limits of PHMB is warranted.