Related Experiment Video

Updated: Jun 23, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

[Risedronate for treatment of osteoporosis]

Hiroshi Hagino1

  • 1School of Health Science, Faculty of Medicine, Tottori University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 13, 2009
PubMed

Insights

Risedronate effectively treats osteoporosis by inhibiting osteoclast activity, significantly reducing vertebral and nonvertebral fracture risks in postmenopausal women. This review highlights its proven efficacy in clinical studies.

Area of Science:

  • Pharmacology
  • Bone Biology
  • Clinical Medicine

Background:

  • Osteoporosis is a significant health concern, increasing fracture risk.
  • Bisphosphonates are a primary treatment for osteoporosis.
  • Risedronate is an approved bisphosphonate medication.

Purpose of the Study:

  • To review the efficacy of risedronate in treating osteoporosis.
  • To summarize clinical evidence supporting risedronate's use.

Main Methods:

  • Review of placebo-controlled, 3-year clinical trials.
  • Analysis of data on fracture risk reduction.
  • Evaluation of risedronate's mechanism of action on osteoclasts.

Main Results:

  • Risedronate strongly decreases bone resorption and turnover.
  • Significant reduction in vertebral fracture risk observed.
  • Significant reduction in nonvertebral fractures, including hip fractures, demonstrated.

Conclusions:

  • Risedronate is an effective treatment for postmenopausal osteoporosis.
  • Clinical trials confirm risedronate's ability to decrease fracture incidence.
  • Risedronate's potent inhibition of osteoclasts underlies its therapeutic benefits.

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.