Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

Parallel Processing

Parallel Processing

The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...

Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

Cross-Sectional Research

Cross-Sectional Research

In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...

Conservative Site-specific Recombination and Phase Variation

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Time-dependent improvement of quality of life with teriparatide or alendronate therapy: a JOINT-05 sub-analysis.

Journal of bone and mineral metabolism·2026

Same author

Time-dependent improvement of quality of life with teriparatide or alendronate therapy: a JOINT-05 sub-analysis.

Journal of bone and mineral metabolism·2025

Same author

Authors' response to 01460, renal dysfunction and its influence on osteoporosis treatment outcomes: a critical review of recent findings.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025

Same author

Frailty and osteoporotic fractures represent mutual risks for each other with common physiological backgrounds.

JBMR plus·2025

Same author

Association Between Sarcopenia and Acupressure Testing in Older Adults Requiring Long-Term Care.

Medicina (Kaunas, Lithuania)·2024

Same author

Association between renal function and fracture incidence during treatment with teriparatide or alendronate: an exploratory subgroup analysis of the Japanese Osteoporosis Intervention Trial-05.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2024

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Published on: November 28, 2025

[A-TOP research group/JOINT program].

Tatsuhiko Kuroda¹, Nobuaki Miyakawa, Teruhiko Miyazaki

¹Comprehensive Support Project for A-TOP, Public Health Research Foundation.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|May 13, 2009

Summary

The Japanese Osteoporosis Intervention Trial (JOINT) studies investigate osteoporosis treatments. JOINT-02 evaluated vitamin D3 and alendronate for fracture prevention, with JOINT-03 examining risedronate and vitamin K2.

More Related Videos

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Published on: October 24, 2018

Related Experiment Videos

Last Updated: Jun 23, 2026

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Automated Joint Space Detection Improves Bone Segmentation Accuracy

Published on: November 28, 2025

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

Published on: October 24, 2018

Area of Science:

Bone Metabolism and Osteoporosis Research
Clinical Trial Design and Execution
Public Health and Epidemiology

Context:

The A-TOP research consortium, established in 2000 by the Japanese Society of Osteoporosis, aims to gather clinical evidence for osteoporosis management.
The Japanese Osteoporosis Intervention Trial (JOINT) program comprises multi-center, randomized, open-label trials registered in clinical trial registries.
Practitioner participation in JOINT trials, including the registration of approximately 2,000 participants in JOINT-02 within three years, indicates strong support for the research objectives.

Purpose:

To confirm the efficacy of combination therapy with active vitamin D3 and alendronate in preventing osteoporotic bone fractures (JOINT-02).
To gather evidence on the combined effects of risedronate and vitamin K2 for osteoporosis treatment (JOINT-03).
To establish a comprehensive osteoporosis database through epidemiological studies (JOB study) for enhanced understanding of osteoporosis in Japan.

Summary:

JOINT-02, initiated in 2003 and concluding in 2009, assessed the combined effects of active vitamin D3 and alendronate on preventing osteoporotic fractures.
JOINT-03 commenced in 2008, focusing on the combination of risedronate and vitamin K2.
Both trials enrolled approximately 2,000 participants, primarily recruited through practitioners, highlighting the clinical relevance and practitioner engagement.

Impact:

Provides crucial clinical evidence for combination therapies in osteoporosis treatment, potentially improving patient outcomes.
Contributes to the development of evidence-based guidelines for osteoporosis management in Japan.
The establishment of an osteoporosis database (JOB study) will enhance epidemiological knowledge and inform future research and public health strategies.