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Updated: Jun 23, 2026

Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

[New aspects of pathogenesis of adhesive process in the abdominal cavity]

S V Minaev, V S Obozin, L T Pustoshkina

    Vestnik Khirurgii Imeni I. I. Grekova
    |May 13, 2009
    PubMed

    Insights

    Polyenzyme therapy significantly reduced intestinal obstruction in children and prevented adhesions in rats. This approach down-regulates inflammatory responses by modulating key growth factors, offering a promising treatment for post-surgical adhesions.

    Area of Science:

    • Surgical pathology
    • Gastroenterology
    • Immunology

    Background:

    • Abdominal adhesions are a primary cause of morbidity and mortality following abdominal surgery.
    • Adhesive intestinal obstruction presents a significant clinical challenge, particularly in pediatric patients.

    Purpose of the Study:

    • To evaluate the efficacy of polyenzyme therapy in managing acute adhesive intestinal obstruction.
    • To investigate the impact of polyenzyme preparations on the development of postoperative abdominal adhesions in a rat model.

    Main Methods:

    • A clinical study involving 126 children with acute adhesive intestinal obstruction, divided into polyenzyme and monoenzyme groups.
    • An experimental study with 70 adult rats, comparing a polyenzyme preparation group with a control group regarding cecal adhesions.
    • Immunohistochemical detection of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and Laminin in rats.

    Main Results:

    • The polyenzyme group showed a lower incidence of intestinal obstruction (1 case) compared to the monoenzyme group (4 cases).
    • Rats receiving polyenzyme preparation exhibited significantly fewer cecal adhesions than the control group (Chi-square test = 23.1, p = 0.001).
    • Polyenzyme therapy normalized levels of angiogenesis factors (VEGF, FGF, Laminin) and down-regulated inflammatory responses mediated by T-lymphocytes and macrophages.

    Conclusions:

    • Polyenzyme therapy demonstrates significant therapeutic potential in reducing postoperative abdominal adhesions and treating adhesive intestinal obstruction.
    • The mechanism involves modulating the expression of key growth factors and inflammatory mediators, thereby mitigating the adhesion cascade.

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