[A search for genetic determinants of premature aging in OXYS rats]

Elucidation of origin of aging is one of the most actual problems of biology. A role of genetic factors in aging processes was shown on different animal models. OXYS rats represent a model of premature aging and age-associated pathologies. The aim of this study is to determine genetic loci for complex of manifestations of premature aging OXYS rats. The QTL associated with development of passive behavior and increased anxiety, were identified in media (100.6 Mb-188.0 Mb) and distal regions (188.0 Mb-250.4 Mb) of chromosome 1 in F2 hybrids obtained by crossing OXYS and control WAG rats. Genes-candidates for QTLwere determined following the data concerning their role in the processes of aging and development of age-related diseases. This data was obtained with the system of automatic extraction of knowledge about molecular-genetic interactions from PubMed abstracts (Laboratory of theoretical genetics, ICaG SB RAS). To confirm contribution of these genes in aging of OXYS rats subsequent gene expression studies are necessary.