Related Experiment Video
Updated: Jun 23, 2026

11:46
Shotgun Lipidomics of Rodent Tissues
Published on: November 18, 2022
[Changes in the lipid peroxidation systems in tissues from various rodent species during aging]
Advances in Gerontology = Uspekhi Gerontologii
|May 13, 2009
Abstract:
The comparative investigation of parameters of the physicochemical regulatory system of the lipid peroxidation (LPO) in liver, spleen and blood components of laboratory rodents of 5 strains and species was carried out. The interrelation between the LPO intensity and the cell-free DNA content in the blood plasma of mice has been shown. The absence of the same type and direct changes of the LPO regulatory system parameters during aging was shown. This is due to modifying effect of those factors as season, the lipid evalability by antioxidants, the species and sex of rodent, diet on the lipid exchange.
Related Concept Videos
Aging
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...