Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Personalized Pharmacotherapy with Sertraline in Patients with Anxiety-Depressive Disorder Based on Omics Biomarkers].

Molekuliarnaia biologiia·2026
Same author

The сontribution of FOXO family transcription factor genes (FOXO1, FOXO3) to chronic obstructive pulmonary disease.

Vavilovskii zhurnal genetiki i selektsii·2025
Same author

[Search for informative predictors of the development and progression of multiple sclerosis].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2025
Same author

[Effect of polymorphic variants of the HTR2A gene on the effectiveness and safety of sertraline in patients with mixed anxiety-depressive disorder].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2025
Same author

[Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease].

Molekuliarnaia biologiia·2025
Same author

Polymorphic variants of the genes for enzymes of the antioxidant system, apoptosis and inflammation as potential predictors of myocardial infarction.

Vavilovskii zhurnal genetiki i selektsii·2024

Related Experiment Video

Updated: Jun 23, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

[Antioxidant gene polymorphism and longevity].

V V Pauk, T R Nasibullin, I A Tuktarova

    Advances in Gerontology = Uspekhi Gerontologii
    |May 13, 2009
    PubMed
    Summary

    Genetic variations in catalase, glutathione peroxidase 1, and methionine sulfoxide reductase A genes were studied in relation to lifespan. Specific gene combinations were linked to longevity in elderly and senile individuals.

    More Related Videos

    Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
    08:46

    Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

    Published on: September 29, 2011

    Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
    10:08

    Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

    Published on: May 18, 2022

    Related Experiment Videos

    Last Updated: Jun 23, 2026

    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
    10:39

    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

    Published on: September 17, 2020

    Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
    08:46

    Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

    Published on: September 29, 2011

    Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
    10:08

    Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

    Published on: May 18, 2022

    Area of Science:

    • Genetics and Aging Research
    • Biochemistry of Oxidative Stress

    Background:

    • Aging is associated with increased oxidative stress.
    • Genetic factors play a role in determining lifespan and age-related disease susceptibility.
    • Polymorphisms in antioxidant enzyme genes may influence healthspan and longevity.

    Purpose of the Study:

    • To investigate the association between specific gene polymorphisms in catalase (CAT), glutathione peroxidase 1 (GPX1), and methionine sulfoxide reductase A (MSRA) and lifespan in an ethnic Tatar population.
    • To analyze the age-related changes in allele and genotype frequencies of these polymorphisms.
    • To identify potential genetic markers for longevity.

    Main Methods:

    • Genotyping of 1534 ethnic Tatar individuals for CAT (-262C/T), GPX1 (L198P), and MSRA (-402C/T) gene polymorphisms using PCR-based methods.
    • Statistical analysis to assess the relationship between genotypes and lifespan.
    • Analysis of allele and genotype frequency distributions across different age groups.

    Main Results:

    • A nonlinear relationship was observed between age and the frequencies of alleles and genotypes for each studied polymorphic marker.
    • The combined genotype CAT*C/*T-GPX1 *L/*L showed a significant association with lifespan, particularly in elderly and senile age groups.
    • Individual polymorphisms did not show a strong linear correlation with lifespan, highlighting the importance of gene combinations.

    Conclusions:

    • Gene-gene interactions, specifically the combination of CAT*C/*T and GPX1 *L/*L genotypes, may contribute to longevity in the studied population.
    • Antioxidant enzyme gene polymorphisms represent potential genetic determinants of human lifespan.
    • Further research is warranted to elucidate the functional mechanisms underlying these associations and their implications for healthy aging.