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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Lipid nanostructures: self-assembly and effect on skin properties
L Barbosa-Barros1, C Barba, G Rodríguez
1Departamento de Tecnologia Quimica y de Tensioactivos, Instituto de Quimica Avanzada de Catalunya, Consejo Superior de Investigaciones Cientificas, C/ Jordi Girona 18-26, 08034 Barcelona, Spain.
Molecular Pharmaceutics
|May 13, 2009
Summary
Lipid nanostructures
Area of Science:
- Lipid self-assembly
- Dermal delivery systems
- Skin barrier function
Background:
- Lipid aggregates like liposomes, bicelles, and micelles are crucial for dermal delivery.
- Understanding the relationship between lipid composition, self-assembly, and skin interaction is vital for optimizing delivery systems.
Purpose of the Study:
- To investigate how varying lipid compositions (DPPC, DMPC, DHPC) and self-assembly structures (liposomes, bicelles, micelles) influence skin parameters.
- To determine the impact of these lipid nanostructures on skin barrier function and hydration.
- To explore the in vitro interaction of lipid nanostructures with the stratum corneum.
Main Methods:
- Characterization of lipid aggregates (liposomes, bicelles, micelles) using electron microscopy and dynamic light scattering.
- Application of lipid nanostructures to skin to assess effects on transepidermal water loss (TEWL) and hydration.
- In vitro incubation of stratum corneum (SC) with lipid nanostructures to observe structural changes.
Main Results:
- Nanostructures with identical assembly but different lipid compositions exhibited distinct effects on skin parameters.
- DMPC-containing systems showed a greater impact on skin barrier function compared to DPPC-containing systems.
- Liposomes generally decreased or maintained TEWL, while bicelles and micelles increased it, leading to diminished skin hydration.
Conclusions:
- Both lipid composition and self-assembly significantly influence the interaction of nanostructures with the skin.
- The thermotropic behavior of lipids at physiological temperatures affects their penetration and interaction within the stratum corneum.
- These findings are critical for designing advanced and targeted skin delivery systems.
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