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Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation
Published on: December 30, 2021
Human adipose-derived stem cells: isolation, characterization and applications in surgery.
Michelle Locke1, John Windsor, P Rod Dunbar
1Dunbar Laboratory, School of Biological Sciences,University of Auckland, 3a Symonds Street, Auckland, New Zealand. michellebjoyce@yahoo.co.nz
ANZ Journal of Surgery
|May 13, 2009
Summary
Adipose-derived stem cells (ASC) from adult fat tissue are ideal for tissue engineering due to abundance and differentiation potential. These cells show promise in wound healing and radiotherapy-damaged tissue repair, with broad surgical applications.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Tissue Engineering
Background:
- Mesenchymal stem cells (MSCs) are crucial for tissue engineering.
- Adult human adipose tissue harbors adipose-derived stem cells (ASC), a type of MSC.
- ASC possess characteristics suitable for regenerative medicine applications.
Purpose of the Study:
- To review the clinical applications of ASC in surgery.
- To discuss ASC isolation, differentiation, and characterization.
- To highlight the potential of ASC in tissue repair and regeneration.
Main Methods:
- Review of current literature on ASC.
- Analysis of ASC isolation and differentiation techniques.
- Examination of clinical trial data for ASC applications.
Main Results:
- ASC are abundant, easily harvested via liposuction, and possess multi-lineage differentiation potential.
- ASC exhibit angiogenic properties and potential in healing radiotherapy-damaged tissue and chronic wounds.
- ASC are being investigated in clinical trials for conditions like Crohn's fistulae.
Conclusions:
- ASC represent a promising stem cell source for various surgical applications.
- Further research into ASC isolation, characterization, and clinical use is warranted.
- ASC hold significant potential for advancing functional tissue engineering and regenerative therapies.
