Related Experiment Video

Updated: Jun 23, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

Pleuropulmonary complications of PVL-positive Staphylococcus aureus infection in children

Biju Thomas1, Arun Pugalenthi, Mark Chilvers

  • 1Children's Hospital, Leicester Royal Infirmary, Leicester, UK.

Acta Paediatrica (Oslo, Norway : 1992)
|May 13, 2009
PubMed

Insights

Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus causes severe pneumonia in children. Early recognition and treatment are crucial for managing serious lung complications from this infection.

Area of Science:

  • Pediatric Infectious Diseases
  • Pulmonology
  • Microbiology

Background:

  • Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus (PVL-SA) is linked to severe community-acquired pneumonia.
  • Community-acquired methicillin-sensitive S. aureus (CA-MSSA) producing PVL toxin can cause aggressive infections.

Observation:

  • Four children with CA-MSSA PVL toxin infection presented with severe pleuropulmonary complications.
  • Manifestations included bilateral infiltrates, pneumatocoeles, pneumothoraces, pleural effusion, empyema, lung abscess, and diaphragmatic paralysis.

Findings:

  • PVL-SA can lead to diverse and severe pleuropulmonary complications in children.
  • These complications underscore the aggressive nature of PVL-SA pneumonia.

Implications:

  • Heightened awareness and early recognition of PVL-SA are vital for prompt diagnosis.
  • Aggressive therapeutic strategies are necessary to manage severe pleuropulmonary disease caused by PVL-SA.
Abstract

More Related Videos

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients07:25

Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients

Published on: July 16, 2020

Related Concept Videos

Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...