Related Experiment Video
Updated: Jun 23, 2026
Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an
E Genç1, M C Avunduk, B Oğuz Genç
1Department of Neurology, Meram School of Medicine, Selcuk University, Konya, Turkey. eminegencduran@gmail.com
Objective:
To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats.
Materials And Methods:
Male Sprague-Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test.
Results:
A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain.
Conclusion:
Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.
