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Updated: Jun 23, 2026

The Successive Alleys Test of Anxiety in Mice and Rats
Published on: June 17, 2013
Laboratory test of a novel structural model of anxiety sensitivity and panic vulnerability
Amit Bernstein1, Michael J Zvolensky, Michael J Zvolensky
1Department of Psychology, University of Haifa, Mount Carmel, Haifa, Israel. abernstein@psy.haifa.ac.il
Abstract:
The current study evaluated a novel latent structural model of anxiety sensitivity (AS) in relation to panic vulnerability among a sample of young adults (N=216). AS was measured using the 16-item Anxiety Sensitivity Index (ASI; Reiss, Peterson, Gursky, & McNally, 1986), and panic vulnerability was indexed by panic attack responding to a single administration of a 4-minute, 10% CO(2) challenge. As predicted, vulnerability for panic attack responding to biological challenge was associated with dichotomous individual differences between taxonic AS classes and continuous within-taxon class individual differences in AS physical concerns. Findings supported the AS taxonic-dimensional hypothesis of AS latent structure and panic vulnerability. These findings are discussed in terms of their theoretical and clinical implications.
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Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.

