Laparoscopic vs open pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy

Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is considered the most common cause of persistent neonatal hypoglycemia. The aim of this study is to compare laparoscopic pancreatectomy with open pancreatectomy for PHHI in one center regarding feasibility, safety, and effectiveness.

A retrospective chart review was conducted for patients managed for PHHI with either laparoscopic or open pancreatectomy for the period from 2001 to 2007 at King Faisal Specialist Hospital and Research Center (Riyadh, Saudi Arabia). Demographic and clinical data were retrieved. Continuous variables were reported as means, and categorical variables were reported as proportions for each group. Means were compared using Student's t test, and proportions were compared using chi(2) test or Fisher's Exact test where appropriate. A P value less than .05 was considered statistically significant. The study proposal was approved by the Clinical Research Committee and the Research Ethics Committee at our institution.

Eighteen patients were managed with pancreatectomy for PHHI for that period: 10 laparoscopic and 8 open. The 2 groups were comparable regarding age and weight at surgery, sex, procedure duration, hospital stay postoperatively, need for reoperation, and development of diabetes mellitus and mental delay. Extent of resection was significantly higher in the open group (P value = .02), and the laparoscopic group was fed significantly earlier (P value = .001). The mean follow-up for the laparoscopic and the open groups were 20.4 months and 46 months, respectively (P value = .004).

Laparoscopic pancreatectomy for PHHI is safe and feasible. Our data suggest its effectiveness compared to the open approach.