Related Experiment Video
Updated: Jun 23, 2026

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
Published on: January 20, 2010
Use of computed tomography to categorize the type of tracheal agenesis
Indira D Panthagani1, Mary C Santos, Carl T D'Angio
1Department of Pediatrics, Strong Children's Research Center, University of Rochester Medical Center, Rochester, NY 14642, USA.
Insights
This study details a rare case of Type I Tracheal Agenesis, a severe congenital condition. Computed tomography aids in diagnosing this fatal disorder in neonates.
Area of Science:
- Medical Science
- Pediatric Surgery
- Radiology
Background:
- Tracheal agenesis is a rare congenital anomaly.
- Type I Tracheal Agenesis involves complete absence of the trachea.
- Associated anomalies are common and contribute to high mortality.
Observation:
- A neonate presented with symptoms suggestive of severe congenital defects.
- Computed tomography (CT) was utilized for diagnostic evaluation.
- The patient exhibited vertebral defects, anal atresia, tracheoesophageal fistula, radial dysplasia, renal defects, and cardiovascular defects.
Findings:
- CT imaging was instrumental in confirming the diagnosis of Type I Tracheal Agenesis.
- The constellation of defects aligns with the VACTERL association.
- The case highlights the diagnostic utility of CT in complex neonatal presentations.
Implications:
- Early and accurate diagnosis of tracheal agenesis is critical for management.
- This rare condition requires a high index of suspicion in non-resuscitatable neonates.
- Multidisciplinary care is essential for managing neonates with multiple congenital anomalies.
Abstract:
We report a case of type I tracheal agenesis with vertebral defects, anal atresia, tracheoesophageal fistula and/or esophageal atresia, radial dysplasia, renal defects, and cardiovascular defects association in which computed tomography was helpful in categorizing the diagnosis. This rare and fatal condition should always be considered when confronted with a neonate impossible to resuscitate at birth.
Related Concept Videos
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Trachea
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of the...
Imaging Studies III: Computed Tomography
Tracheostomy: Procedure and Tubes
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...

