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Long remission in muscle-specific kinase antibody-positive juvenile myasthenia
Banu Anlar1, Vuslat Yilmaz, Güher Saruhan-Direskeneli
1Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey. banlar@hacettepe.edu.tr
Abstract:
The clinical course of anti-muscle specific kinase-positive myasthenia in children has been little reported. Described here is the case of an 8 year-old boy who presented with ptosis and generalized weakness, which resolved within 1 month without any immunomodulatory treatment. This spontaneous remission lasted 6 years and was then followed by a relapse with bulbar symptoms. The patient was put on plasmapheresis; after initial benefit, symptoms worsened and serum antibody levels persisted. This case constitutes an example of the variability of the clinical presentation, course, and therapeutic response in anti-muscle specific kinase-positive myasthenia in childhood.
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