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Iatrogenic eyelid granulomata

David Haider1, Robert Wynn, S Ahmed Sadiq

  • 1Manchester Royal Eye Hospital, Manchester, UK. dhaider@nhs.net

American Journal of Therapeutics
|May 13, 2009
PubMed

Insights

A new antifungal drug, posaconazole, may be linked to eyelid granulomata. Discontinuing the medication reduced symptoms, while restarting it caused them to worsen.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Infectious Diseases

Background:

  • Posaconazole is a novel systemic antifungal agent.
  • Eyelid granulomata are inflammatory lesions affecting the eyelids.

Observation:

  • A pediatric patient presented with bilateral eyelid granulomata.
  • The granulomata showed a temporal relationship with posaconazole use.

Findings:

  • Discontinuation of posaconazole led to a reduction in granuloma size and symptoms.
  • Resumption of posaconazole therapy resulted in an exacerbation of symptoms.

Implications:

  • This case suggests a potential adverse effect of posaconazole.
  • Further investigation is warranted to confirm the association between posaconazole and eyelid granulomata.

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