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Updated: Jun 23, 2026

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

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Iatrogenic eyelid granulomata.

David Haider¹, Robert Wynn, S Ahmed Sadiq

¹Manchester Royal Eye Hospital, Manchester, UK. dhaider@nhs.net

American Journal of Therapeutics

|May 13, 2009

Summary

A new antifungal drug, posaconazole, may be linked to eyelid granulomata. Discontinuing the medication reduced symptoms, while restarting it caused them to worsen.

Area of Science:

Ophthalmology
Dermatology
Infectious Diseases

Background:

Posaconazole is a novel systemic antifungal agent.
Eyelid granulomata are inflammatory lesions affecting the eyelids.

Observation:

A pediatric patient presented with bilateral eyelid granulomata.
The granulomata showed a temporal relationship with posaconazole use.

Findings:

Discontinuation of posaconazole led to a reduction in granuloma size and symptoms.
Resumption of posaconazole therapy resulted in an exacerbation of symptoms.

Implications:

This case suggests a potential adverse effect of posaconazole.
Further investigation is warranted to confirm the association between posaconazole and eyelid granulomata.

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