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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 23, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

MicroRNAs and cardiac pathology.

Michael V G Latronico1, Gianluigi Condorelli

  • 1MultiMedica Hospital, Milan, Italy.

Nature Reviews. Cardiology
|May 13, 2009
PubMed
Summary

MicroRNAs (miRNAs) are small regulatory RNAs crucial for gene expression. Recent research highlights their significant role in cardiovascular pathology and heart disease, prompting extensive investigation.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiology

Background:

  • MicroRNAs (miRNAs) are endogenous, short regulatory RNA molecules.
  • Initially discovered for their role in developmental timing in roundworms, miRNAs are now recognized as fundamental gene expression regulators across many organisms.
  • Their significance extends beyond development, with emerging roles in mammalian physiology and pathology.

Purpose of the Study:

  • To comprehensively review the current literature on microRNAs and heart disease.
  • To elucidate the physiological pathways regulated by miRNAs in the heart.
  • To understand the involvement of miRNAs in cardiovascular pathology.

Main Methods:

  • Literature review of published studies on miRNAs and heart disease.

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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Related Experiment Videos

Last Updated: Jun 23, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

  • Analysis of research investigating miRNA roles in cardiac physiology.
  • Examination of studies focusing on miRNA involvement in cardiovascular diseases.

    • Main Results:

    • The first report on miRNAs in the heart was published in 2005.
    • Intense research is ongoing to understand miRNA-regulated pathways in the heart.
    • Evidence suggests miRNAs are involved in various cardiovascular pathologies.

    Conclusions:

    • MicroRNAs play a critical role in heart function and disease.
    • Further research is essential to fully understand the therapeutic potential of targeting miRNAs in cardiovascular conditions.
    • This review synthesizes the current knowledge on miRNAs in heart disease.