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Background and Environment Affect Phenotype

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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

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Published on: April 23, 2015

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.

Johannes Beckers¹, Wolfgang Wurst, Martin Hrabé de Angelis

¹Institute of Experimental Genetics, Helmholtz Zentrum München, GmbH, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. beckers@helmholtz-muenchen.de

Nature Reviews. Genetics

|May 13, 2009

Summary

Mice are crucial for genetic research and modeling human diseases. Future efforts will enhance their value by improving disease modeling, comprehensive phenotyping, and environmental impact analysis.

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Area of Science:

Genetics and Genomics
Mammalian Model Organisms
Translational Medicine

Background:

Mice are the primary mammalian model for genetic research and human disease studies.
International initiatives are creating a comprehensive map of mouse gene functions.
Maximizing the mouse model's utility for human disease research presents ongoing challenges.

Purpose of the Study:

To outline challenges and future directions for enhancing the mouse as a model organism for human diseases.
To emphasize the need for improved genotypic disease modeling in mice.
To highlight the importance of systemic and systematic phenotyping and environmental factor assessment.

Main Methods:

Focus on generating genetically accurate mouse models of human diseases.
Implementing comprehensive, system-wide phenotyping of mouse mutant resources.
Investigating the influence of environmental factors on observed phenotypes.

Main Results:

Current international projects are mapping mouse gene functions, a first for any mammalian genome.
Significant challenges remain in optimizing mouse models for human disease research.
Key areas for advancement include genotypic accuracy, comprehensive phenotyping, and environmental interaction analysis.

Conclusions:

The mouse remains a vital model organism, but its potential for human disease research requires further development.
Future research must focus on creating better genotypic models, thorough phenotyping, and understanding environmental influences.
These advancements will maximize the mouse's value in understanding and treating human diseases.