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Galectin-8 expression in laryngeal squamous cell carcinoma.
Geun Woo Dong1, Jun Kim, Jun Hee Park
1Department of Otorhinolaryngology-Head and Neck Surgery, Chosun University College of Medicine, Gwangju, Korea.
Clinical and Experimental Otorhinolaryngology
|May 13, 2009
Summary
Galectin-8 expression correlates with advanced stages in laryngeal squamous cell carcinoma (LSCC). This finding suggests galectin-8 may serve as a prognostic factor for LSCC patients, potentially aiding personalized treatment strategies.
Area of Science:
- Oncology
- Biomarker Research
Background:
- Laryngeal squamous cell carcinoma (LSCC) treatment outcomes remain modest due to a lack of personalized therapies.
- Galectin-8 expression is observed in various tissues and may correlate with squamous cell carcinoma malignancy.
Purpose of the Study:
- To evaluate galectin-8 expression in LSCC.
- To investigate the correlation between galectin-8 expression and clinicopathologic factors (primary stage, nodal involvement, clinical stage, histologic grade).
Main Methods:
- Immunohistochemical staining for galectin-8 was performed on 77 LSCC patient paraffin-embedded tissue specimens.
- Specimens were collected from patients diagnosed between 1993 and 2007.
Main Results:
- Strong positive galectin-8 expression was significantly correlated with T-stages, nodal stages, and clinical stages of LSCC.
- No significant correlation was found between galectin-8 expression and the histopathologic grade in LSCC.
Conclusions:
- Galectin-8 protein expression is a potential prognostic factor for patients diagnosed with LSCC.
- These findings may contribute to developing more individualized treatment approaches for LSCC.
