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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Related Experiment Video

Updated: Jun 23, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Small cell carcinoma originating from the cavernous sinus.

Hiroshi Nakaguchi1, Akira Matsuno, Satoru Miyawaki

  • 1Department of Neurosurgery, Teikyo University Chiba Medical Center, Ichihara, Japan. hnakaguchi@hi-ho.ne.jp

Acta Neurochirurgica
|May 13, 2009
PubMed
Summary

This case study details a rare intracranial small cell carcinoma in the cavernous sinus. The patient achieved complete remission with combined radiosurgery and chemotherapy.

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Last Updated: Jun 23, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Ophthalmology

Background:

  • Presents a rare case of small cell carcinoma originating in the cavernous sinus.
  • Highlights the unusual intracranial origin of this neuroendocrine tumor.

Observation:

  • A 55-year-old male presented with sudden onset oculomotor and abducens palsy.
  • MRI revealed a 3-cm mass in the right cavernous sinus extending to the middle cranial fossa.

Findings:

  • Biopsy confirmed small cell carcinoma.
  • Treatment with radiosurgery and chemotherapy (cisplatin/VP-16) resulted in dramatic tumor shrinkage.
  • Complete remission was achieved, with recovery from extraocular muscle paresis.

Implications:

  • This is the first reported case of intracranial small cell carcinoma.
  • Suggests neuroendocrine cells in the cranium can be a site for small cell carcinoma.
  • Demonstrates the efficacy of combined modality treatment for this rare tumor.