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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Validation of the standardization framework SSTR-RADS 1.0 for neuroendocrine tumors using the novel SSTR‑targeting peptide [<sup>18</sup>F]SiTATE.

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[Imaging of neuroendocrine tumors of the gastrointestinal tract : Value of (hybrid) imaging diagnostics in radiology].

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Biodistribution and first clinical results of <sup>18</sup>F-SiFAlin-TATE PET: a novel <sup>18</sup>F-labeled somatostatin analog for imaging of neuroendocrine tumors.

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Related Experiment Video

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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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Gene therapy in thyroid cancer.

C Spitzweg1

  • 1Department of Internal Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany. Christine.Spitzweg@med.uni-muenchen.de

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 13, 2009
PubMed
Summary

Gene therapy shows great potential for treating advanced thyroid cancer, particularly when combined with other treatments. Promising strategies like NIS gene therapy allow for targeted radionuclide delivery and noninvasive monitoring.

Area of Science:

  • Oncology
  • Molecular Biology
  • Radiotherapy

Background:

  • Follicular cell-derived and medullary thyroid cancer present significant treatment challenges, especially in advanced and metastatic stages.
  • Current treatment modalities for thyroid cancer have limitations, necessitating the exploration of novel therapeutic strategies.

Purpose of the Study:

  • To review and evaluate the potential of various gene therapy approaches for treating thyroid cancer.
  • To highlight the promise of NIS (sodium-iodide symporter) gene therapy combined with radionuclide therapy for thyroid cancer treatment.

Main Methods:

  • Review of existing literature on gene therapy strategies for thyroid cancer, including corrective, cytoreductive, and immunomodulatory approaches.
  • Focus on NIS gene transfer combined with targeted radionuclide therapy (e.g., (131)I, (188)Re, (211)At).

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  • Discussion of vector systems, including replication-selective viral vectors and biodegradable polymers, for efficient and safe systemic gene delivery.

    • Main Results:

    • Gene therapy approaches demonstrate high potential for advanced and dedifferentiated thyroid cancer, especially within multimodality treatment plans.
    • NIS gene therapy offers dual functionality as both a therapeutic agent and a reporter gene for noninvasive imaging and monitoring.
    • The bystander effect associated with some gene therapies can compensate for limited vector spread within tumors.

    Conclusions:

    • Gene therapy holds significant promise for the future treatment of advanced thyroid cancer, particularly when integrated into multimodality strategies.
    • Overcoming challenges in tumor-specific targeting and minimizing toxicity are crucial for clinical translation.
    • NIS gene therapy, with its imaging capabilities, is essential for planning and monitoring individualized thyroid cancer treatment.