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Enhanced haloperidol-induced prolactin stimulation with chronic neuroleptic treatment in the rat
1Research Service, Veterans Administration Medical Center, Syracuse, New York 13210.
Life Sciences
|January 1, 1991
Abstract:
Animals were treated either acutely, or chronically for 21 days, with a low dose (0.1 mg/kg) of haloperidol, then sacrificed to obtain trunk blood for radioimmunoassay of prolactin (PRL) level. PRL concentrations on day 21 of chronic treatment were greater than two-fold those produced by acute neuroleptic. Challenge with apomorphine to rats withdrawn for 48 hours revealed similar PRL reductions as a group withdrawn from chronic vehicle injections.