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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
PPE Use in Healthcare Settings II: Doffing01:10

PPE Use in Healthcare Settings II: Doffing

The sequence of removing or doffing PPE starts with the gloves, as they are the most contaminated. Next is removal of the face shield or goggles, as they would interfere with removing other PPE. Then remove the gown, followed by the mask or respirator. Perform hand hygiene between steps if hands become contaminated and immediately after removing all PPE. Generally, the outside front and sleeves of the isolation gown, the goggles or the mask, the respirator, and the face shield are contaminated.

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Related Experiment Video

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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

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Published on: March 24, 2023

[Occupational allergic contact dermatitis in Dakar].

Suzanne Oumou Niang1, Mohamed Cissé, Fall Mame Coumba Gaye

  • 1Service de Dermatologie du CHU Le Dantec de Dakar BP 3001. suzeoumou@yahoo.com

Le Mali Medical
|May 14, 2009
PubMed
Summary

Occupational contact dermatitis is rising in Senegal, with dichromate of potassium and formaldehyde being key allergens. Prevention through protective gear and worker education is crucial to reduce incidence.

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Area of Science:

  • Dermatology
  • Occupational Health
  • Allergology

Context:

  • Rising incidence of occupational dermatitis globally due to new allergens and industrial processes.
  • Occupational contact dermatitis cases in Senegal are underreported to social security institutions.
  • Need for epidemiological data on occupational contact dermatitis in Senegal.

Purpose:

  • Determine the frequency of occupational allergic contact dermatitis in Senegal.
  • Identify the specific allergens responsible for occupational contact dermatitis.
  • Identify occupations at highest risk for occupational contact dermatitis.

Summary:

  • A prospective study identified 27 cases of occupational contact dermatitis among 201 patients over one year.
  • Predominant sectors affected include building, mechanics, health, cleaning, and trade.
  • Key allergens identified were potassium dichromate, N-isopropyl N-phenylparaphenylenediamine, fragrance mix, thiuram mix, colophane, formaldehyde, nickel sulfate, and chalk.

Impact:

  • Highlights the significant role of potassium dichromate in cement and formaldehyde in paints within the building sector.
  • Identifies N-isopropyl N-phenylparaphenylenediamine in rubber and fragrance mix in oils as causes in mechanics.
  • Points to thiuram mix in gloves and potassium dichromate in antiseptics as sources for health workers.
  • Emphasizes the need for enhanced prevention strategies, including personal protective equipment and increased medical surveillance and worker information.