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Related Experiment Video

Updated: Jun 23, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

[Occult multicentric breast cancer].

S V Vtorushin, M V Zab'ialova, S A Glushchenko

    Voprosy Onkologii
    |May 14, 2009
    PubMed
    Summary

    Multicentric invasive ductal breast cancer, often found in central breast regions, is associated with larger tumors, higher grade, and distinct receptor expression profiles. This finding aids in understanding breast cancer heterogeneity.

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    Area of Science:

    • Oncology
    • Breast Cancer Research
    • Pathology

    Context:

    • Invasive ductal breast cancer (IDCa) is the most common type of breast cancer.
    • Understanding tumor growth patterns like unicentricity and multicentricity is crucial for treatment planning.
    • Previous research has explored various factors influencing IDCa progression and characteristics.

    Purpose:

    • To investigate the characteristics and prevalence of multicentric tumor growth in invasive ductal breast cancer.
    • To identify clinical and histological features associated with multicentric breast cancer.
    • To correlate multicentricity with tumor grade, size, and biomarker status (sex hormone receptors, Her2).

    Summary:

    • This study analyzed 92 patients with invasive ductal breast cancer (stages T2-4N0-2M0-1).
    • Multicentric tumor growth was identified in 44 cases, often associated with macroscopically identifiable nodes in central breast segments and tumors >3 cm.
    • Multicentric tumors were predominantly Grade III, with lower sex hormone receptor expression and positive Her2 status.

    Impact:

    • Highlights the clinical significance of multicentricity in invasive ductal breast cancer.
    • Provides insights into the specific characteristics of multicentric tumors, aiding in diagnosis and treatment stratification.
    • Suggests potential differences in therapeutic response based on tumor growth patterns and biomarker status.

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