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Updated: Jun 23, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
[A simplified model for kinetics of a tumor cells' population]
Abstract:
A mathematical model of solid tumor growth is suggested. The external influence from the tumor-bearing organism is described separately for cell growth and apoptosis. The model is an ordinary differential equation which provides for use of a variety of dependences for both processes. A solution for a specific example of the processes is obtained in the form of a generalized logistic curve. Our results give clues for such experimental phenomena as spontaneous cessation of cell growth, dependence of life duration on insignificant variations in apoptosis, etc.
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