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Published on: December 8, 2014
Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection
Bjorn L Herpers1, Bart Vlaminckx, Olaf Burkhardt
1Department of Medical Microbiology and Immunology, St. Antonius Hospital, PO Box 2500, Nieuwegein 3430 EM, The Netherlands. b.herpers@antonius.net
Abstract:
Clostridium difficile infection (CDI) has become more refractory to standard therapy. We describe 4 patients with severe refractory CDI who were successfully treated with tigecycline. Symptoms improved within 1 week. No relapses were observed. This favorable outcome suggests that tigecycline might be a useful alternative for treating severe refractory CDI.
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