Related Experiment Video

Updated: Jun 23, 2026

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
06:00

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates

Published on: January 15, 2018

First ultrasound-mediated one-pot synthesis of N-substituted amides

Rajendra M Srivastava1, Ricardo A W Neves Filho, Cecilia A da Silva

  • 1Departamento de Quimica Fundamental, Universidade Federal de Pernambuco, 50.740-540 Recife, PE, Brazil. rms_indu@yahoo.com

Ultrasonics Sonochemistry
|May 14, 2009
PubMed

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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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