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Updated: Jun 23, 2026
09:19
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
[Conducting a cost-effectiveness trial in oncology: justification and method]
C Lejeune1, C Binquet, F Bonnetain
1Inserm U866, Université de Bourgogne, Dijon cedex, France. catherine.lejeune@u-bourgogne.fr
Bulletin Du Cancer
|May 14, 2009
Summary
This paper explores medico-economic trials in oncology, proposing cost and efficacy as primary endpoints. Such trials can guide budget allocation for public health by evaluating treatment strategies.
Area of Science:
- Health Economics
- Oncology Research
- Clinical Trial Design
Context:
- Limited financial resources necessitate efficient healthcare budget allocation.
- Emerging oncology strategies like "stop and go" chemotherapy require rigorous evaluation beyond efficacy.
- Traditional clinical trials often lack medico-economic endpoints, limiting resource optimization.
Purpose:
- To outline the design of medico-economic trials, focusing on objectives, methodologies, and sample size calculations.
- To propose composite endpoints that integrate cost and efficacy for comparing therapeutic strategies.
- To provide a framework for designing trials that assess both clinical effectiveness and economic value.
Summary:
- This review focuses on designing medico-economic trials, particularly in oncology, where financial constraints drive the need for cost-effectiveness analysis.
- It suggests using a composite endpoint combining medical costs and patient efficacy to evaluate new treatment strategies, such as reduced chemotherapy administration.
- The paper details objectives, methods, and sample size considerations for these integrated trials, offering an alternative to traditional efficacy-only clinical trials.
Impact:
- Facilitates the design of more resource-conscious clinical trials in healthcare.
- Supports evidence-based decision-making for budget allocation in public health and oncology.
- Enables a comprehensive assessment of therapeutic interventions, balancing clinical benefit with economic implications.
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