Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2020
Same author

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping.

Science advances·2020
Same author

Neuroprotection requires the functions of the RNA-binding protein HuR.

Cell death and differentiation·2014
Same author

DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows.

Nucleic acids research·2013
Same author

RAGE: a multi-ligand receptor unveiling novel insights in health and disease.

Current medicinal chemistry·2010
Same author

DIANA-microT web server: elucidating microRNA functions through target prediction.

Nucleic acids research·2009

Related Experiment Video

Updated: Jun 23, 2026

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
07:07

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

DIANA-mirPath: Integrating human and mouse microRNAs in pathways.

G L Papadopoulos1, P Alexiou, M Maragkakis

  • 1Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 16602 Varkiza, Greece. papadopoulos@fleming.gr

Bioinformatics (Oxford, England)
|May 14, 2009
PubMed
Summary

DIANA-mirPath is a free web tool that identifies molecular pathways affected by microRNAs. It analyzes single or multiple microRNAs to reveal pathway alterations and their combinatorial effects, aiding interpretation.

More Related Videos

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Related Experiment Videos

Last Updated: Jun 23, 2026

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
07:07

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • MicroRNAs (miRNAs) play crucial roles in gene regulation.
  • Identifying pathways affected by miRNAs is essential for understanding biological processes.
  • Existing tools may not fully capture the combinatorial effects of multiple miRNAs.

Purpose of the Study:

  • To introduce DIANA-mirPath, a web-based computational tool.
  • To enable the identification of molecular pathways potentially altered by miRNA expression.
  • To account for the combinatorial effects of co-expressed miRNAs on pathway modulation.

Main Methods:

  • DIANA-mirPath performs enrichment analysis of miRNA target genes against KEGG pathways.
  • It compares sets of miRNA targets to known KEGG pathways.
  • The tool simultaneously analyzes multiple miRNAs to assess combinatorial effects.

Main Results:

  • DIANA-mirPath identifies molecular pathways modulated by single or multiple miRNAs.
  • The software considers the combined impact of co-expressed miRNAs on pathway regulation.
  • Graphical output facilitates the interpretation and visualization of pathway alterations.

Conclusions:

  • DIANA-mirPath is a valuable web-based tool for miRNA pathway analysis.
  • It simplifies the identification and interpretation of miRNA-mediated pathway modulation.
  • The tool aids researchers in understanding the functional impact of miRNAs on biological pathways.